CCHMC DNA Sequencing and Genotyping Core

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Comprehensive Production and Analysis of Genetic Data
DNA Sequencing, Genotyping, SNP characterization


The DNA Sequencing and Genotyping Core is an institutional (non-profit) laboratory centralizing the production and analysis of DNA related data. Equipped with state-of-the-art instrumentation the facility provides services for:
  • Next Generation DNA sequencing
  • Conventional (Sanger) sequencing
  • Whole genome genotyping on the Illumina platform (Infinium assay)
  • Whole genome methylation analysis
  • Translational research for gene based studies
Operating under Clinical Laboratory Improvement Amendments (CLIA) certification the facility can provide results for both research and molecular diagnostic purposes. Our technical team has extensive training in:
  • NGS Data quality control
  • Sequencing/Genotyping project management
  • Primer design and PCR optimization
  • Genomic database searches
  • Bioinformatic handling of large datasets
Established in 2001 at the Cincinnati Children's Hospital Research Foundation, the DNA Sequencing and Genotyping Core has been a major player in the sequencing of the Pneumocystis carinii genome.

We are dedicated to the success of the researchers and clinicians that we serve!